Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Participation of the Intrinsically Disordered Regions of the bHLH-PAS Transcription Factors in Disease Development.

International journal of molecular sciences - 11 Mar 2021

Kolonko-Adamska Marta, Uversky Vladimir N, Greb-Markiewicz Beata

Abstract excerpt

The basic helix-loop-helix/Per-ARNT-SIM (bHLH-PAS) proteins are a family of transcription factors regulating expression of a wide range of genes involved in different functions, ranging from differentiation and development control by oxygen and toxins sensing to circadian clock setting. In addition to the well-preserved DNA-binding bHLH and PAS domains, bHLH-PAS proteins contain long intrinsically disordered...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Receptor Nuclear Translocator
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intrinsically Disordered Proteins

Share to Mutation, Missense

Share to Receptors, Aryl Hydrocarbon

Share to Repressor Proteins

Share to RNA Processing, Post-Transcriptional

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 33799876
DOI: 10.3390/ijms22062868
PMCID: PMC8001110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Participation of the Intrinsically Disordered Regions of the bHLH-PAS Transcription Factors in Disease Development.PMID 33799876Read ↗

The Participation of the Intrinsically Disordered Regions of the bHLH-PAS Transcription Factors in Disease DevelopmentSemantic proximity Read ↗

An activity-specificity trade-off encoded in human transcription factors.Semantic proximity Read ↗

Phase Separation as a Missing Mechanism for Interpretation of Disease Mutations.Semantic proximity Read ↗

The PRALINE database: Protein and Rna humAn singLe nucleotIde variaNts in condEnsatesSemantic proximity Read ↗

Missense mutations in intrinsically disordered protein regions link pathogenicity and phase separationSemantic proximity Read ↗

Decoding Missense Variants by Incorporating Phase Separation via Machine LearningSemantic proximity Read ↗

Cooption of polyalanine tract into a repressor domain in the mammalian transcription factor HoxA11Semantic proximity Read ↗

Is there a role of phase partitioning in coordinating DNA damage response?Semantic proximity Read ↗

Condensate formation of the human RNA-binding protein SMAUG1 is controlled by its intrinsically disordered regions and interactions with 14-3-3 proteinsSemantic proximity Read ↗

Core and Flanking bHLH-PAS:DNA interactions mediate specificity and drive obesitySemantic proximity Read ↗

Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology.Semantic proximity Read ↗

DisPhaseDB, an integrative database of diseases related variations in liquid-liquid phase separation proteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.