Article

A proteome-wide dependency map of protein interaction motifs

2024-09-11

Abstract excerpt

Short linear motifs (SLiMs) are the most ubiquitous protein interaction modules within unstructured regions of the human proteome, yet their contribution to cellular homeostasis remains poorly understood. To systematically assess SLiM function, we applied base editing to mutate all reported and a set of computationally predicted SLiMs defined by SLiM-like evolutionary patterns. By screening 7,293 SLiM-containing r...

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Literature Corpus work: bda1fd80-c8d6-5b8f-878b-afb2b695a475
DOI: 10.1101/2024.09.11.612445

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