Functional Classification and Interaction Selectivity Landscape of the Human SH3 Domain Superfamily

Abstract excerpt

SRC homology 3 (SH3) domains are critical interaction modules that orchestrate the assembly of protein complexes involved in diverse biological processes. They facilitate transient protein-protein interactions by selectively interacting with proline-rich motifs (PRMs). A database search revealed 298 SH3 domains in 221 human proteins. Multiple sequence alignment of human SH3 domains is useful for phylogenetic analy...

Topics

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• Amino Acid Sequence
• Cell Adhesion Molecules Research
• Chemical Synthesis and Analysis
• Mutation
• Peptidase Inhibition and Analysis
• Protein Binding
• Protein Kinase Regulation and GTPase Signaling
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

4c6da84f-428f-527e-811b-74ef034f6ee0

DOI

10.20944/preprints202312.1043.v1