Article

SpY-C: Supervised Learning of Phosphopeptide Sequence Constraints Enables Global Prediction of SH2 Domain Binding

2026-08-19

Abstract excerpt

<h4>ABSTRACT</h4> Tyrosine kinase signaling for cell development and homeostasis in multicelluar organisms and a major biochemical contribution is by driving interactions between phosphorylated tyrosines (pY) and SH2 domain containing proteins. This assembly is so important to driving cell outcomes that a wide variety of experimental and computational approaches have been used to understand which SH2-pY interacti...

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Literature Corpus work: 5407fdd6-fd90-512f-ae16-a8f2c7e886ca
DOI: 10.64898/2026.08.18.744962

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