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A Systematic Compilation of Human SH3 Domains: A Versatile Superfamily in Cellular Signaling

12 Aug 2023

Abstract excerpt

SRC homology 3 (SH3) domains are fundamental modules that enable the assembly of protein complexes through physical interactions with a pool of proline-rich/noncanonical motifs from partner proteins. They are widely studied modular building blocks across all five kingdoms of life and viruses, mediating various biological processes. The SH3 domains are also implicated in the development of human diseases, such as...

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PMID: 37626864
DOI: 10.3390/cells12162054

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