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Article

Structure of the PRYSPRY-domain: implications for autoinflammatory diseases.

FEBS letters - 9 Jan 2006

Grütter Christian, Briand Christophe, Capitani Guido, Mittl Peer R E, Papin Stephanie, Tschopp Jürg, Grütter Markus G

Abstract excerpt

We determined the first structure of PRYSPRY, a domain found in over 500 different proteins, involved in innate immune signaling, cytokine signaling suppression, development, cell growth and retroviral restriction. The fold encompasses a 7-stranded and a 6-stranded antiparallel beta-sheet, arranged in a beta-sandwich. In the crystal, PRYSPRY forms a dimer where the C-terminus of an acceptor molecule binds to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16364311
DOI: 10.1016/j.febslet.2005.11.076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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