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Article

A proteome-wide dependency map of protein interaction motifs.

Nature structural & molecular biology - 1 Mar 2026

Ambjørn Sara M, Meeusen Bob, Kliche Johanna, Wang Juanjuan, Garvanska Dimitriya H, Kruse Thomas, Lopez Mendez Blanca, Mann Matthias, Mailand Niels, Hertz Emil P T, Davey Norman E, Nilsson Jakob

Abstract excerpt

Short linear motifs (SLiMs) are the most ubiquitous protein interaction motifs within unstructured regions of the human proteome, yet their contribution to cellular homeostasis remains poorly understood. Here, to systematically assess SLiM function, we applied base editing to mutate all reported and a set of computationally predicted SLiMs defined by SLiM-like evolutionary patterns. By screening 7,293...

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Identifiers

PMID: 41792279
DOI: 10.1038/s41594-026-01762-2

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HAP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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