Functional Classification and Interaction Selectivity Landscape of the Human SH3 Domain Superfamily

Abstract excerpt

SRC homology 3 (SH3) domains are critical interaction modules that orchestrate the assembly of protein complexes involved in diverse biological processes. They facilitate transient protein-protein interactions by selectively interacting with proline-rich motifs (PRMs). A database search revealed 298 SH3 domains in 221 human proteins. Multiple sequence alignment of human SH3 domains is useful for phylogenetic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chemical Synthesis and Analysis
• Share to Peptidase Inhibition and Analysis
• Share to Protein Kinase Regulation and GTPase Signaling