Article

Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells

2020-03-31

Abstract excerpt

<h4>ABSTRACT</h4> The cGAS-STING pathway is a major mechanism that mammalian cells utilize to detect cytoplasmic dsDNA from incoming viruses, bacteria, or self. CYCLIC GMP-AMP SYNTHASE (cGAS) is the sensor protein that directly binds dsDNAs. cGAS synthesizes cyclic GMP-AMP (cGAMP), which binds to the adaptor STIMULATOR OF INTERFERON GENES (STING), activating an INTERFERON REGULATORY FACTOR 3 (IRF3)-mediated immun...

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Literature Corpus work: 88f68923-71dc-5502-9a56-28a8bfcd6186
DOI: 10.1101/2020.03.30.016535

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