Article

High-Throughput Screening and Initial SAR Studies Identify a Novel Sub-micromolar Potent Human cGAS Inhibitor

2025-08-22

Abstract excerpt

Cyclic GMP-AMP synthase (cGAS) has emerged as a promising therapeutic target of several human diseases, including Alzheimer’s disease (AD) and other neurodegenerative disorders. As a cytosolic DNA sensor, cGAS generates an innate immune response to promote neuroinflammation by producing an endogenous agonist of the stimulator of interferon genes (STING), 2’3’-cyclic GMP-AMP (cGAMP), which activates the cGAS–STING...

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Literature Corpus work: 46863c39-13ca-5cf2-bb2d-cb26fb8d4cd9
DOI: 10.1101/2025.08.18.670979

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