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Article

Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response

28 Apr 2020

Abstract excerpt

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the downstream stimulator of interferon genes (STING) acting as essential immune-surveillance mediators have become hot topics of research. The intrinsic function of the cGAS-STING pathway facilitates type-I interferon (IFN) inflammatory signaling responses and other cellular processes such as autophagy, cell survival, senescence....

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PMID: 32411126
DOI: 10.3389/fimmu.2020.00615

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