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Function and regulation of cGAS-STING signaling in infectious diseases

6 Feb 2023

Abstract excerpt

The efficacious detection of pathogens and prompt induction of innate immune signaling serve as a crucial component of immune defense against infectious pathogens. Over the past decade, DNA-sensing receptor cyclic GMP-AMP synthase (cGAS) and its downstream signaling adaptor stimulator of interferon genes (STING) have emerged as key mediators of type I interferon (IFN) and nuclear factor-κB (NF-κB) responses in...

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PMID: 36825026
DOI: 10.3389/fimmu.2023.1130423

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