Article

cGLRs are a diverse family of pattern recognition receptors in animal innate immunity

2023-02-22

Abstract excerpt

<h4>Summary</h4> cGAS (cyclic GMP-AMP synthase) is an enzyme in human cells that controls an immune response to cytosolic DNA. Upon binding DNA, cGAS synthesizes a nucleotide signal 2′3′-cGAMP that activates the protein STING and downstream immunity. Here we discover cGAS-like receptors (cGLRs) constitute a major family of pattern recognition receptors in animal innate immunity. Building on recent analysis in Dr...

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Literature Corpus work: 0a44d333-e9c6-50d4-93fa-c9ba5a2eed1b
DOI: 10.1101/2023.02.22.529553

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