Article

Roles of the cGAS-STING Pathway in Cancer Immunosurveillance and Immunotherapy

2019-03-04

Abstract excerpt

Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that initiates innate immune responses. DNA-bound cGAS produces cyclic GMP-AMP (cGAMP), which activates stimulator of interferon genes (STING) to induce inflammatory cytokines and other immune mediators. cGAS detects DNA without sequence specificity and responds to both cytosolic foreign DNA from pathogens and self-DNA leaked into the cytosol due to genome i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 12f3ed41-e256-5b88-ab73-5f88646231c1
DOI: 10.1146/annurev-cancerbio-030518-055636

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Roles of the cGAS-STING Pathway in Cancer Immunosurveillance and ImmunotherapyDOI 10.1146/annurev-cancerbio-030518-055636Read

Significance of the cGAS-STING Pathway in Health and DiseaseSemantic proximity Read

Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseasesSemantic proximity Read

Regulation of the cGAS-STING PathwaySemantic proximity Read

Regulation of cGAS‐Mediated Immune Responses and ImmunotherapySemantic proximity Read

The Cytosolic DNA-Sensing cGAS–STING Pathway in CancerSemantic proximity Read

Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory ResponseSemantic proximity Read

Innate Immune Response to Cytoplasmic DNA: Mechanisms and DiseasesSemantic proximity Read

The triggers of the cGAS-STING pathway and the connection with inflammatory and autoimmune diseasesSemantic proximity Read

cGAS‐STING pathway: post‐translational modifications and functions in sterile inflammatory diseasesSemantic proximity Read

cGAMP the travelling messengerSemantic proximity Read

DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment RemodelingSemantic proximity Read

Advances in cGAS-STING Signaling Pathway and DiseasesSemantic proximity Read