Article

Combining polygenic risk scores to understand genetic liability to physical-mental health multimorbidity in UK BioBank

2025-10-21

Abstract excerpt

<h4>Background</h4> Internalising and CardioMetabolic MultiMorbidity (ICM-MM) is a common form of mental-physical health multimorbidity, yet its genetic predisposition is largely unknown. We examined the polygenic nature of ICM-MM by assessing single trait-specific polygenic risk scores (PRS TRAIT ) and whether combining them could increase the proportion of variance in liability to ICM-MM explained by genetic v...

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Literature Corpus work: 88b1b1bc-9aaa-5c5f-977f-1beb31b1ac62
DOI: 10.1101/2025.10.20.25338357

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