Shared Genetic Liability across Systems of Psychiatric and Physical Illness.

Abstract excerpt

Epidemiological literature describes widespread psychiatric-physical comorbidity. However, the extent to which observed bivariate risk is transdiagnostic remains uncertain. We apply Genomic SEM and introduce Genomic E-SEM, an exploratory factor-analytic extension of Genomic SEM, here applied to 73 physical outcomes (~1.9 million cases) across eight medical domains. We then modeled latent physical illness factors...

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