Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combining polygenic risk scores to understand genetic liability to physical-mental health multimorbidity in UK Biobank.

Human molecular genetics - 15 Apr 2026

Stow Daniel, Tsang Ruby S M, Katzourou Ioanna K, Underwood Jack F G, Holmans Peter, Barroso Inês, Martin Hilary, van den Bree Marianne B M, Finer Sarah, Timpson Nicholas J

Abstract excerpt

BACKGROUND: Multimorbidity, also known as multiple long-term conditions, is a major public health concern. Internalising and CardioMetabolic MultiMorbidity (ICM-MM) is a common form of mental-physical health multimorbidity, yet its genetic predisposition is largely unknown. We examined the polygenic nature of ICM-MM by assessing single trait-specific polygenic risk scores (PRSTRAIT) and whether combining them...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Biological Specimen Banks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Genetic Risk Score

Share to Genome-Wide Association Study

Share to Multifactorial Inheritance

Share to UK Biobank

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 42044059
DOI: 10.1093/hmg/ddag012
PMCID: PMC13116345

Genes

CS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combining polygenic risk scores to understand genetic liability to physical-mental health multimorbidity in UK Biobank.PMID 42044059Read ↗

Combining polygenic risk scores to understand genetic liability to physical-mental health multimorbidity in UK BioBankSemantic proximity Read ↗

Early-life hallmarks of polygenic liability to adult internalizing-cardiometabolic multimorbiditySemantic proximity Read ↗

Polygenic risk modeling with latent trait-related genetic componentsSemantic proximity Read ↗

Polygenic risk modeling with latent trait-related genetic components.Semantic proximity Read ↗

A multivariate genome-wide association study of psycho-cardiometabolic multimorbidity.Semantic proximity Read ↗

Identifying and characterizing disease subpopulations that most benefit from polygenic risk scores.Semantic proximity Read ↗

A global overview of genetically interpretable multimorbidities among common diseases in the UK Biobank.Semantic proximity Read ↗

Genetic liability to physical health conditions influences comorbidities in individuals with severe mental illnessSemantic proximity Read ↗

Shared Genetic Liability across Systems of Psychiatric and Physical Illness.Semantic proximity Read ↗

Metabolic Polygenic Risk Scores for Prediction of Obesity, Type 2 Diabetes, and Related MorbiditiesSemantic proximity Read ↗

Polygenic risk of psychiatric disorders exhibits cross-trait associations in electronic health record dataSemantic proximity Read ↗

The multivariate genetic architecture of psychiatric and insulin resistance multimorbidity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.