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Article

Hailey-Hailey disease models identify synergistic therapeutic effects of MEK and ROCK inhibition

2026-05-23

Abstract excerpt

<h4>ABSTRACT</h4> Hailey-Hailey disease (HHD) is a genetic skin blistering disorder lacking approved treatments despite linkage to ATP2C1 variants 25 years ago. Since knockout mice did not replicate HHD, we ablated ATP2C1 in human keratinocytes or chemically inhibited its encoded Golgi calcium pump SPCA1. In organotypic epidermis, SPCA1 deficiency or inhibition reproduced HHD pathology, disrupting desmosomal ca...

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Literature Corpus work
888c2c3e-363d-56c0-8e17-0b7f70a29194
DOI
10.64898/2026.05.20.726679
Open publication

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Hailey-Hailey disease models identify synergistic therapeutic effects of MEK and ROCK inhibitionDOI 10.64898/2026.05.20.726679
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