Article

Insulin-Regulated Actin Dynamics is Disrupted in a Human Keratinocyte Model of Hailey Hailey Disease

2025-12-17

Abstract excerpt

Hailey Hailey Disease (HHD) is an autosomal dominant cutaneous disorder caused by mutations in ATP2C1 , the gene encoding the Golgi/secretory pathway Ca 2+ -ATPase SPCA1. Characterized by suprabasal acantholysis and intertriginous blistering of the skin, HHD treatment focuses on managing symptoms as there is no cure. Challenges to targeted therapy are due to the lack of facile and reliable models, both human and...

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Literature Corpus work: a241b944-c6e6-5c72-8c91-e6362773f90e
DOI: 10.64898/2025.12.15.694174

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