Recalcitrant Hailey-Hailey disease successfully treated with topical ruxolitinib cream and dupilumab

Abstract excerpt

Hailey-Hailey disease (HHD) is a rare, chronic autosomal dominant dermatosis characterized by erythematous, painful vesicles and erosions at sites of friction. Individuals with HHD have a mutation on chromosome 3q 21-24 in the ATP2C1 gene causing a defect in the Ca2+/Mn2+ ATPase secretory pathway in the Golgi complex, resulting in abnormal intracellular calcium homeostasis.1 This pump defect leads to impaired...

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