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Article

Pumping the Breaks on Acantholytic Skin Disorders: Targeting Calcium Pumps, Desmosomes, and Downstream Signaling in Darier, Hailey-Hailey, and Grover Disease.

The Journal of investigative dermatology - 1 Mar 2025

Harmon Robert M, Ayers Jessica L, McCarthy Erin F, Kowalczyk Andrew P, Green Kathleen J, Simpson Cory L

Abstract excerpt

Acantholytic skin disorders, by definition, compromise intercellular adhesion between epidermal keratinocytes. The root cause of blistering in these diseases traces back to direct disruption of adhesive cell-cell junctions, exemplified by autoantibody-mediated attack on desmosomes in pemphigus. However, genetic acantholytic disorders originate from more indirect mechanisms. Darier disease and Hailey-Hailey...

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Identifiers

PMID: 39207315
DOI: 10.1016/j.jid.2024.06.1289
PMCID: PMC11846705

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Pumping the Breaks on Acantholytic Skin Disorders: Targeting Calcium Pumps, Desmosomes, and Downstream Signaling in Darier, Hailey-Hailey, and Grover Disease.PMID 39207315Read ↗

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