Article
How do keratinizing disorders and blistering disorders overlap?
Experimental dermatology - 1 Feb 2013
Hamada Takahiro, Tsuruta Daisuke, Fukuda Shunpei, Ishii Norito, Teye Kwesi, Numata Sanae, Dainichi Teruki, Karashima Tadashi, Ohata Chika, Furumura Minao, Hashimoto Takashi
Abstract excerpt
Inherited keratinizing disorders are caused by mutations in the genes encoding cornified cell envelope proteins, enzymes and their inhibitors, adhesion molecules, cytoskeletal proteins and others in the epidermis. These molecules are known to regulate differentiation, proliferation and cell adhesions. Intriguingly, some keratinizing disorders show blistering skin lesions, while some inherited blistering disorders...
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