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Article

Hailey-Hailey disease: clinical, diagnostic and therapeutic update.

Anais brasileiros de dermatologia - 1 Jan 2000

Porro Adriana Maria, Arai Seque Camila, Miyamoto Denise, Vanderlei Medeiros da Nóbrega Diego, Simões E Silva Enokihara Milvia Maria, Giuli Santi Claudia

Abstract excerpt

Hailey-Hailey disease is a rare genodermatosis described in 1939, with an autosomal dominant inheritance pattern, characterized by compromised adhesion between epidermal keratinocytes. It has an estimated prevalence of 1/50,000, with no gender or race predilection. It results from a heterozygous mutation in the ATP2C1 gene, which encodes the transmembrane protein hSPA1C, present in all tissues, with preferential...

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Identifiers

PMID: 38789364
DOI: 10.1016/j.abd.2023.12.003
PMCID: PMC11343000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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