Article

Transcriptional profiling of rare acantholytic disorders suggests common mechanisms of pathogenesis

2022-12-03

Abstract excerpt

<h4>Background</h4> Darier, Hailey-Hailey, and Grover’s diseases are rare non-autoimmune acantholytic skin diseases. While these diseases have different underlying causes, they share defects in cell-cell adhesion in the epidermis and desmosome organization. <h4>Objective</h4> To better understand the underlying mechanisms leading to disease in these conditions we performed RNA-seq on lesional skin samples from D...

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Literature Corpus work: 94d54f17-b699-5495-bdba-a269b8444920
DOI: 10.1101/2022.12.02.518412

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