Article

Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier disease

2023-03-07

Abstract excerpt

<h4>ABSTRACT</h4> Mutation of the ATP2A2 gene encoding sarco-endoplasmic reticulum calcium ATPase 2 (SERCA2) was linked to Darier disease more than two decades ago; however, there remain no targeted therapies for this disorder causing recurrent skin blistering and infections. Since Atp2a2 knockout mice do not phenocopy its pathology, we established a human tissue model of Darier disease to elucidate its pathoge...

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Literature Corpus work: 95ccd289-abdc-52d4-8a73-6bf33ae718af
DOI: 10.1101/2023.03.07.531620

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