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Article

Calcium pumps and keratinocytes: lessons from Darier's disease and Hailey-Hailey disease.

The British journal of dermatology - 1 May 2004

Dhitavat J, Fairclough R J, Hovnanian A, Burge S M

Abstract excerpt

Darier's disease and Hailey-Hailey disease are autosomal dominantly inherited skin disorders in which desmosomal adhesion between keratinocytes is abnormal. ATP2A2 and ATP2C1 have been identified as the causative genes for Darier's disease and Hailey-Hailey disease, respectively. ATP2A2 encodes the sarco(endo)plasmic reticulum Ca(2+)-ATPase isoform 2 (SERCA2) pump, while ATP2C1 encodes a secretory pathway...

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Identifiers

PMID: 15149492
DOI: 10.1111/j.1365-2133.2004.05904.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Calcium pumps and keratinocytes: lessons from Darier's disease and Hailey-Hailey disease.PMID 15149492Read ↗

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Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier diseaseSemantic proximity Read ↗

Activity of the hSPCA1 Golgi Ca2+ pump is essential for Ca2+-mediated Ca2+ response and cell viability in Darier diseaseSemantic proximity Read ↗

Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier diseaseSemantic proximity Read ↗

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SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease.Semantic proximity Read ↗

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