Article

ATP2C1 knockdown induces abnormal expressions of cytoskeletal and tight junction proteins mimicking Hailey–Hailey disease

2023-08-10

Abstract excerpt

Hailey–Hailey disease (HHD) is a rare, autosomal, dominant, and hereditary skin disorder characterized by epidermal acantholysis. The HHD-associated gene ATPase calcium-transporting type 2C member 1 (ATP2C1) encodes the protein secretory pathway Ca2 + ATPase1 (SPCA1), playing a critical role in HHD pathogenesis. Therefore, we aimed to investigate the effect of ATP2C1 knockdown on keratinocyte cultures that mimicke...

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Literature Corpus work: ba2bc157-c3f6-5966-86eb-08b8ca8cdfaa
DOI: 10.21203/rs.3.rs-3234403/v1

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