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Article

A bacterial mutational footprint in colorectal cancer genomes.

British journal of cancer - 1 May 2021

Rosendahl Huber Axel, Pleguezuelos-Manzano Cayetano, Puschhof Jens

Abstract excerpt

Changes in the microbiome are associated with the development of colorectal cancer, but causal explanations have been lacking. We recently demonstrated that pks+ Escherichia coli induce a specific mutational pattern using intestinal organoids and these mutations are present in the genomes of colorectal cancer. This finding warrants further studies on the microbial role in oncogenic mutation induction, cancer...

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Colon
DNA Damage
Gastrointestinal Microbiome
Host Microbial Interactions
INDEL Mutation

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PMID: 33742142
DOI: 10.1038/s41416-021-01273-5
PMCID: PMC8144397

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