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Article

Colibactin mutational signatures in NTHL1 tumor syndrome and MUTYH associated polyposis patients.

Genes, chromosomes & cancer - 1 Jan 2024

Terlouw D, Boot A, Ducarmon Q R, Nooij S, Jessurun M A, van Leerdam M E, Tops C M, Langers A M J, Morreau H, van Wezel T, Nielsen M

Abstract excerpt

Polyketide synthase (pks) island harboring Escherichia coli are, under the right circumstances, able to produce the genotoxin colibactin. Colibactin is a risk factor for the development of colorectal cancer and associated with mutational signatures SBS88 and ID18. This study explores colibactin-associated mutational signatures in biallelic NTHL1 and MUTYH patients. Targeted Next Generation Sequencing (NGS) was...

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Identifiers

PMID: 37795928
DOI: 10.1002/gcc.23208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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