Article
Asynchrony between virus diversity and antibody selection limits influenza virus evolution.
eLife - 11 Nov 2020
Morris Dylan H, Petrova Velislava N, Rossine Fernando W, Parker Edyth, Grenfell Bryan T, Neher Richard A, Levin Simon A, Russell Colin A
Abstract excerpt
Seasonal influenza viruses create a persistent global disease burden by evolving to escape immunity induced by prior infections and vaccinations. New antigenic variants have a substantial selective advantage at the population level, but these variants are rarely selected within-host, even in previously immune individuals. Using a mathematical model, we show that the temporal asynchrony between within-host virus...
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