Article

Parallel HIV-1 fitness landscapes shape viral dynamics in humans and macaques that develop broadly neutralizing antibodies

2024-07-16

Abstract excerpt

Human immunodeficiency virus (HIV)-1 evolves within individual hosts to escape adaptive immune responses while maintaining its capacity for replication. Coevolution between HIV-1 and the immune system generates extraordinary viral genetic diversity. In some individuals, this process also results in the development of broadly neutralizing antibodies (bnAbs) that can neutralize many viral variants, a key focus of HI...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ce2fe35b-a6e4-5ed3-88ad-c92ec31f00bc
DOI: 10.1101/2024.07.12.603090

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Parallel HIV-1 fitness landscapes shape viral dynamics in humans and macaques that develop broadly neutralizing antibodiesDOI 10.1101/2024.07.12.603090Read

Host-pathogen coevolution and the emergence of broadly neutralizing antibodies in chronic infectionsSemantic proximity Read

Functional Convergence of Genetically Diverse B-Cell Receptors in Simian-HIV Infected Rhesus MacaquesSemantic proximity Read

SIV infection duration largely determines broadening of neutralizing antibody response in macaques.Semantic proximity Read

Determinants of HIV-1 broadly neutralizing antibody induction.Semantic proximity Read

Virological features associated with the development of broadly neutralizing antibodies to HIV-1.Semantic proximity Read

Fierce selection and interference in B-cell repertoire response to chronic HIV-1Semantic proximity Read

The genetic interaction between HIV and the antibody repertoireSemantic proximity Read

Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution.Semantic proximity Read

Broadly neutralizing antibodies developed by an HIV-positive elite neutralizer exact a replication fitness cost on the contemporaneous virus.Semantic proximity Read

Signatures of selection in the human antibody repertoire: Selective sweeps, competing subclones, and neutral driftSemantic proximity Read

Strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins.Semantic proximity Read

Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies.Semantic proximity Read