Article
Asynchrony between virus diversity and antibody selection limits influenza virus evolution
2020-04-29
Abstract excerpt
Seasonal influenza viruses create a persistent global disease burden by evolving to escape immunity induced by prior infections and vaccinations. New antigenic variants have a substantial selective advantage at the population level, but these variants are rarely selected within-host, even in previously immune individuals. Using a mathematical model, we show that the temporal asynchrony between within-host virus ex...
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Identifiers and source
- Literature Corpus work
- bb1a0b7c-e469-508a-9059-9f1b70ea768a
- DOI
- 10.1101/2020.04.27.064915