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Antibody vs. HIV in a clash of evolutionary titans

11 Oct 2005

Abstract excerpt

HIV has evolved many strategies to avoid neutralizing antibody responses, particularly to conserved regions on the external glycoprotein spikes of the virus. Nevertheless, a small number of antibodies have been evolved by the human immune system to recognize conserved parts of the glycoproteins, and therefore, have broadly neutralizing cross-strain activities. These antibodies constitute important tools in the...

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PMID: 16219699
DOI: 10.1073/pnas.0505126102

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