Article
Competitive exclusion by autologous antibodies can prevent broad HIV-1 antibodies from arising.
Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2015
Luo Shishi, Perelson Alan S
Abstract excerpt
The past decade has seen the discovery of numerous broad and potent monoclonal antibodies against HIV type 1 (HIV-1). Eliciting these antibodies via vaccination appears to be remarkably difficult, not least because they arise late in infection and are highly mutated relative to germline antibody sequences. Here, using a computational model, we show that broad antibodies could in fact emerge earlier and be less...
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