APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's disease.

doi:10.1186/s13195-020-00628-z

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APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's disease.

Alzheimer's research & therapy - 27 May 2020

Konijnenberg Elles, Tijms Betty M, Gobom Johan, Dobricic Valerija, Bos Isabelle, Vos Stephanie, Tsolaki Magda, Verhey Frans, Popp Julius, Martinez-Lage Pablo, Vandenberghe Rik, Lleó Alberto, Frölich Lutz, Lovestone Simon, Streffer Johannes, Bertram Lars, Blennow Kaj, Teunissen Charlotte E, Veerhuis Robert, Smit August B, Scheltens Philip, Zetterberg Henrik, Visser Pieter Jelle

Abstract excerpt

BACKGROUND: Aggregation of amyloid β into plaques in the brain is one of the earliest pathological events in Alzheimer's disease (AD). The exact pathophysiology leading to dementia is still uncertain, but the apolipoprotein E (APOE) ε4 genotype plays a major role. We aimed to identify the molecular pathways associated with amyloid β aggregation using cerebrospinal fluid (CSF) proteomics and to study the potential...

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PMID: 32460813
DOI: 10.1186/s13195-020-00628-z
PMCID: PMC7254647

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