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Article

The evolutionary turnover of recombination hot spots contributes to speciation in mice.

Genes & development - 1 Feb 2016

Smagulova Fatima, Brick Kevin, Pu Yongmei, Camerini-Otero R Daniel, Petukhova Galina V

Abstract excerpt

Meiotic recombination is required for the segregation of homologous chromosomes and is essential for fertility. In most mammals, the DNA double-strand breaks (DSBs) that initiate meiotic recombination are directed to a subset of genomic loci (hot spots) by sequence-specific binding of the PRDM9 protein. Rapid evolution of the DNA-binding specificity of PRDM9 and gradual erosion of PRDM9-binding sites by gene...

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Share to Biological Evolution
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Speciation

Share to Histone-Lysine N-Methyltransferase

Share to Hybridization, Genetic

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Share to Recombination, Genetic

Source

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Identifiers

PMID: 26833728
DOI: 10.1101/gad.270009.115
PMCID: PMC4743057

Genes

PRDM9

Provenance

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