Article

Large disruptions to mammalian spermatogenesis downstream of genetic perturbations in meiotic double-strand break repair

2026-05-18

Abstract excerpt

Fertility in mammalian species depends on the successful pairing of homologous chromosomes, mediated by formation of DNA double-strand breaks and a process of homology search involved in repairing these breaks. PRDM9, the most rapidly evolving mammalian protein, which specifies the positioning of breaks where it binds to DNA, also facilitates homology search and chromosome pairing in settings where it “symmetrical...

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Literature Corpus work: c61196d2-5eaa-52ed-8962-e817498071a0
DOI: 10.64898/2026.05.14.724910

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