Article

Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways

2022-11-18

Abstract excerpt

<h4> Abstract </h4> Globally decreased histone 3, lysine 27 tri-methylation (H3K27me3) is a hallmark of H3K27-altered diffuse midline gliomas (DMGs) and group-A posterior fossa ependymomas (PFAs). H3K27-altered DMGs are largely characterized by lysine-to- methionine mutations in histone 3 at position 27 (H3K27M). Most PFAs overexpress EZH inhibitory protein (EZHIP), which possesses a region of similarity to the...

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Literature Corpus work: 35f992be-fe8c-5ff9-af65-2345db3e7212
DOI: 10.1101/2022.11.17.516833

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