Article
Identification of a differentiation stall in epithelial mesenchymal transition in histone H3-mutant diffuse midline glioma.
GigaScience - 15 Dec 2020
Sanders Lauren M, Cheney Allison, Seninge Lucas, van den Bout Anouk, Chen Marissa, Beale Holly C, Kephart Ellen Towle, Pfeil Jacob, Learned Katrina, Lyle A Geoffrey, Bjork Isabel, Haussler David, Salama Sofie R, Vaske Olena M
Abstract excerpt
BACKGROUND: Diffuse midline gliomas with histone H3 K27M (H3K27M) mutations occur in early childhood and are marked by an invasive phenotype and global decrease in H3K27me3, an epigenetic mark that regulates differentiation and development. H3K27M mutation timing and effect on early embryonic brain development are not fully characterized. RESULTS: We analyzed multiple publicly available RNA sequencing datasets to...
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