Article
Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes.
Scientific reports - 7 Mar 2023
Ajuyah Pamela, Mayoh Chelsea, Lau Loretta M S, Barahona Paulette, Wong Marie, Chambers Hazel, Valdes-Mora Fatima, Senapati Akanksha, Gifford Andrew J, D'Arcy Colleen, Hansford Jordan R, Manoharan Neevika, Nicholls Wayne, Williams Molly M, Wood Paul J, Cowley Mark J, Tyrrell Vanessa, Haber Michelle, Ekert Paul G, Ziegler David S, Khuong-Quang Dong-Anh
Abstract excerpt
Diffuse midline gliomas (DMG) harbouring H3K27M mutation are paediatric tumours with a dismal outcome. Recently, a new subtype of midline gliomas has been described with similar features to DMG, including loss of H3K27 trimethylation, but lacking the canonical H3K27M mutation (H3-WT). Here, we report a cohort of five H3-WT tumours profiled by whole-genome sequencing, RNA sequencing and DNA methylation profiling...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.