Article

Reduced insulin signalling in neurons induces sex-specific health benefits

2022-09-19

Abstract excerpt

Reduced activity of the insulin/IGF signalling (IIS) network extends healthspan and lifespan in mammals and possibly humans. Loss of the Irs1 gene increases survival in mice and causes tissue-specific changes in gene expression. However, the tissues underlying IIS mediated longevity are currently unknown. Here we measured survival and healthspan in male and female animals lacking Irs1 activity specifically in the...

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Literature Corpus work: 87b7310d-a5b8-51c6-9157-2514ffcc30ec
DOI: 10.1101/2022.09.19.508502

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