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Article

Tissue‐specific insulin signaling in the regulation of metabolism and aging

1 Jul 2014

Abstract excerpt

In mammals, insulin signaling regulates glucose homeostasis and plays an essential role in metabolism, organ growth, development, fertility, and lifespan. The defects in this signaling pathway contribute to various metabolic diseases such as type 2 diabetes, polycystic ovarian disease, hypertension, hyperlipidemia, and atherosclerosis. However, reducing the insulin signaling pathway has been found to increase...

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PMID: 25087968
DOI: 10.1002/iub.1293

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