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Article

Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan.

Aging cell - 1 Aug 2017

Merry Troy L, Kuhlow Doreen, Laube Beate, Pöhlmann Doris, Pfeiffer Andreas F H, Kahn C Ronald, Ristow Michael, Zarse Kim

Abstract excerpt

Impaired insulin/IGF1 signalling has been shown to extend lifespan in model organisms ranging from yeast to mammals. Here we sought to determine the effect of targeted disruption of the insulin receptor (IR) in non-neuronal tissues of adult mice on the lifespan. We induced hemizygous (PerIRKO+/- ) or homozygous (PerIRKO-/- ) disruption of the IR in peripheral tissue of 15-weeks-old mice using a...

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Identifiers

PMID: 28544360
DOI: 10.1111/acel.12610
PMCID: PMC5506415

Genes

IGF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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