Article
Reducing Igf-1r levels leads to paradoxical and sexually dimorphic effects in HD mice.
PloS one - 1 Jan 2014
Corrochano Silvia, Renna Maurizio, Osborne Georgina, Carter Sarah, Stewart Michelle, May Joel, Bates Gillian P, Brown Steve D M, Rubinsztein David C, Acevedo-Arozena Abraham
Abstract excerpt
Many of the neurodegenerative diseases that afflict people in later life are associated with the formation of protein aggregates. These so-called "proteinopathies" include Alzheimer's disease (AD) and Huntington's disease (HD). The insulin/insulin-like growth factor signalling (IIS) pathway has been proposed to modulate such diseases in model organisms, as well as the general ageing process. In this pathway,...
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