Article

Affinity-engineered human antibodies detect celiac disease gluten pMHC complexes and inhibit T-cell activation

2019-11-15

Abstract excerpt

Antibodies specific for antigenic peptides bound to major histocompatibility complex (MHC) molecules are valuable tools for studies of antigen presentation. Such T-cell receptor (TCR)-like antibodies may also have therapeutic potential in human disease due to their ability to target disease-associated antigens with high specificity. We previously generated celiac disease (CeD) relevant TCR-like antibodies that rec...

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Literature Corpus work: 8787f4e8-4c5e-5dae-9216-41dd5d3fe0ec
DOI: 10.1101/840561

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