Article
Restricted VH/VL usage and limited mutations in gluten-specific IgA of coeliac disease lesion plasma cells.
Nature communications - 9 Jun 2014
Steinsbø Øyvind, Henry Dunand Carole J, Huang Min, Mesin Luka, Salgado-Ferrer Marlene, Lundin Knut E A, Jahnsen Jørgen, Wilson Patrick C, Sollid Ludvig M
Abstract excerpt
Coeliac disease (CD), an enteropathy caused by cereal gluten ingestion, is characterized by CD4(+) T cells recognizing deamidated gluten and by antibodies reactive to gluten or the self-antigen transglutaminase 2 (TG2). TG2-specific immunoglobulin A (IgA) of plasma cells (PCs) from CD lesions have limited somatic hypermutation (SHM). Here we report that gluten-specific IgA of lesion-resident PCs share this...
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