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Article

Discriminative T-cell receptor recognition of highly homologous HLA-DQ2–bound gluten epitopes

20 Nov 2018

Abstract excerpt

Celiac disease (CeD) provides an opportunity to study the specificity underlying human T-cell responses to an array of similar epitopes presented by the same human leukocyte antigen II (HLA-II) molecule. Here, we investigated T-cell responses to the two immunodominant and highly homologous HLA-DQ2.5-restricted gluten epitopes, DQ2.5-glia-α1a (PFPQPELPY) and DQ2.5-glia-ω1 (PFPQPEQPF). Using...

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PMID: 30455354
DOI: 10.1074/jbc.ra118.005736

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