Article
Stereotyped antibody responses target posttranslationally modified gluten in celiac disease.
JCI insight - 7 Sept 2017
Snir Omri, Chen Xi, Gidoni Moriah, du Pré M Fleur, Zhao Yuguang, Steinsbø Øyvind, Lundin Knut Ea, Yaari Gur, Sollid Ludvig M
Abstract excerpt
The role of B cells and posttranslational modifications in pathogenesis of organ-specific immune diseases is increasingly envisioned but remains poorly understood, particularly in human disorders. In celiac disease, transglutaminase 2-modified (TG2-modified; deamidated) gluten peptides drive disease-specific T cell and B cell responses, and antibodies to deamidated gluten peptides are excellent diagnostic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.