Article
Celiac disease: from pathogenesis to novel therapies.
Gastroenterology - 1 Dec 2009
Schuppan Detlef, Junker Yvonne, Barisani Donatella
Abstract excerpt
Celiac disease has become one of the best-understood HLA-linked disorders. Although it shares many immunologic features with inflammatory bowel disease, celiac disease is uniquely characterized by (1) a defined trigger (gluten proteins from wheat and related cereals), (2) the necessary presence of HLA-DQ2 or HLA-DQ8, and (3) the generation of circulating autoantibodies to the enzyme tissue transglutaminase (TG2)....
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