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HSB-1/HSF-1 pathway modulates histone H4 in mitochondria to control mtDNA transcription and longevity

21 Oct 2020

Abstract excerpt

Here, we found that increased HSF-1 activity elevates histone H4 levels in somatic tissues during development, while knockdown of H4 completely suppresses HSF-1-mediated longevity. Moreover, overexpression of H4 is sufficient to extend life span. Ablation of HSB-1 induces an H4-dependent increase in micrococcal nuclease protection of both nuclear chromatin and mitochondrial DNA (mtDNA), which consequently results...

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PMID: 33087356
DOI: 10.1126/sciadv.aaz4452

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